Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.2
USERS' SCORE
Good
Based on 11 Reviews
8.2
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
7
Vitamin E (as dl-Alpha tocopheryl acetate)
68 mg
453%
Coenzyme Q10
100 mg
**
Top Medical Research Studies
9
We delved into the effects of coenzyme Q10 (CoQ10) supplementation on cholesterol levels in adults to determine how it can influence lipid profiles. Through a thorough meta-analysis of fifty randomized controlled trials involving nearly 2800 participants, we explored its potential benefits for reducing cholesterol levels effectively.
Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.
Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.
Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.
Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.
Read More
9
Coenzyme Q10 aids cholesterol management
We explored the impact of coenzyme Q10 on high cholesterol in patients with polycystic ovary syndrome (PCOS) as part of a broader analysis of various nutritional supplements. The study involved a systematic review and network meta-analysis of forty-one randomized controlled trials, including 2,362 patients in total.
Our findings indicated that coenzyme Q10 was notably effective in improving lipid levels, particularly in reducing triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). It outperformed other supplements in these areas, suggesting that it may play a crucial role in managing cholesterol levels for individuals with PCOS.
However, it's important to note that while coenzyme Q10 demonstrated efficacy in lipid metabolism, the study did not show significant benefits for other health markers, like high-density lipoprotein cholesterol (HDL-C) or testosterone levels. This points to a need for more in-depth research to fully understand its potential and effectiveness in relation to individual health outcomes within this patient group.
Overall, our analysis suggests coenzyme Q10 could be a viable option for helping to manage high cholesterol in PCOS patients, although further high-quality studies are essential for confirming these results and understanding the broader implications.
Our findings indicated that coenzyme Q10 was notably effective in improving lipid levels, particularly in reducing triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). It outperformed other supplements in these areas, suggesting that it may play a crucial role in managing cholesterol levels for individuals with PCOS.
However, it's important to note that while coenzyme Q10 demonstrated efficacy in lipid metabolism, the study did not show significant benefits for other health markers, like high-density lipoprotein cholesterol (HDL-C) or testosterone levels. This points to a need for more in-depth research to fully understand its potential and effectiveness in relation to individual health outcomes within this patient group.
Overall, our analysis suggests coenzyme Q10 could be a viable option for helping to manage high cholesterol in PCOS patients, although further high-quality studies are essential for confirming these results and understanding the broader implications.
Read More
8
CoQ10 improves cholesterol removal functions
We conducted a 24-week study to see how coenzyme Q10 (CoQ10) might help people with high cholesterol levels, specifically by examining its effects on high-density lipoprotein (HDL) function. A total of 101 participants with dyslipidemia were randomly assigned to either a CoQ10 group, which received 120 mg daily, or a placebo group.
We measured how well HDL could help remove cholesterol from the body, known as cholesterol efflux capacity (CEC), along with indicators of inflammation. Our results showed that those taking CoQ10 had a remarkable improvement in how effectively their HDL worked to remove cholesterol and also experienced a reduction in HDL inflammation after 24 weeks.
Interestingly, we noticed that the benefits of CoQ10 appeared to be even stronger in older adults, women, and non-obese individuals. However, CoQ10 didn’t make a significant difference in HDL oxidation levels. Overall, we found that adding CoQ10 to the diet could be a great way to enhance heart health for people struggling with high cholesterol.
We measured how well HDL could help remove cholesterol from the body, known as cholesterol efflux capacity (CEC), along with indicators of inflammation. Our results showed that those taking CoQ10 had a remarkable improvement in how effectively their HDL worked to remove cholesterol and also experienced a reduction in HDL inflammation after 24 weeks.
Interestingly, we noticed that the benefits of CoQ10 appeared to be even stronger in older adults, women, and non-obese individuals. However, CoQ10 didn’t make a significant difference in HDL oxidation levels. Overall, we found that adding CoQ10 to the diet could be a great way to enhance heart health for people struggling with high cholesterol.
Read More
Most Useful Reviews
7.5
Youthful appearance
2 people found this helpful
This is my favourite product that I have used for years. It's helpful for blood pressure and cholesterol. I take one pill twice daily, and people often comment that I look younger than my age, thanks to this supplement. I’m delighted to have found it on iHerb due to their fast shipping and excellent prices!
Read More
9
Normalised heartbeat
1 people found this helpful
My husband has had a consistently high heartbeat. After starting this supplement once daily, his heartbeat is back to normal. It also provides a boost of energy and concentration. I’m thrilled that iHerb stocks the Qunol brand.
Read More
9
Eliminated aches
1 people found this helpful
My cholesterol medication caused muscle aches, but after adding CoQ10 to my regimen, my achy arms no longer hurt by week two. It works effectively!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.2
- All Researches
9
Coenzyme Q10 aids cholesterol management
We explored the impact of coenzyme Q10 on high cholesterol in patients with polycystic ovary syndrome (PCOS) as part of a broader analysis of various nutritional supplements. The study involved a systematic review and network meta-analysis of forty-one randomized controlled trials, including 2,362 patients in total.
Our findings indicated that coenzyme Q10 was notably effective in improving lipid levels, particularly in reducing triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). It outperformed other supplements in these areas, suggesting that it may play a crucial role in managing cholesterol levels for individuals with PCOS.
However, it's important to note that while coenzyme Q10 demonstrated efficacy in lipid metabolism, the study did not show significant benefits for other health markers, like high-density lipoprotein cholesterol (HDL-C) or testosterone levels. This points to a need for more in-depth research to fully understand its potential and effectiveness in relation to individual health outcomes within this patient group.
Overall, our analysis suggests coenzyme Q10 could be a viable option for helping to manage high cholesterol in PCOS patients, although further high-quality studies are essential for confirming these results and understanding the broader implications.
Our findings indicated that coenzyme Q10 was notably effective in improving lipid levels, particularly in reducing triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). It outperformed other supplements in these areas, suggesting that it may play a crucial role in managing cholesterol levels for individuals with PCOS.
However, it's important to note that while coenzyme Q10 demonstrated efficacy in lipid metabolism, the study did not show significant benefits for other health markers, like high-density lipoprotein cholesterol (HDL-C) or testosterone levels. This points to a need for more in-depth research to fully understand its potential and effectiveness in relation to individual health outcomes within this patient group.
Overall, our analysis suggests coenzyme Q10 could be a viable option for helping to manage high cholesterol in PCOS patients, although further high-quality studies are essential for confirming these results and understanding the broader implications.
Read More
9
Combined supplements lower cholesterol
We conducted a study to explore the lipid-lowering effects of a dietary supplement that included coenzyme Q10 as well as other natural extracts. Specifically, we wanted to see how these components could help lower cholesterol levels in individuals with mild hypercholesterolemia. Our study involved 105 participants who had slightly elevated low-density lipoprotein (LDL) cholesterol levels, categorized as mild hypercholesterolemia, and were randomly split into different treatment groups for eight weeks.
One group followed lifestyle changes alone, while the others received either a low or high dosage of monacolin K, a component of red yeast rice, alongside coenzyme Q10, grape seed, and olive leaf extracts. Over the treatment period, we found that both doses of monacolin K significantly reduced LDL cholesterol levels—26.46% with the higher dose and 16.77% with the lower dose.
While we saw some positive results relating to cholesterol reduction, the slight benefit attributed specifically to the coenzyme Q10 was not clearly defined, as it was part of a combination treatment. However, importantly, no severe adverse events were reported, suggesting that this supplement approach is safe for mild high cholesterol management. Overall, our findings suggest that lower-dose monacolin K combined with these natural extracts can be a helpful option for those looking to improve their cholesterol levels.
One group followed lifestyle changes alone, while the others received either a low or high dosage of monacolin K, a component of red yeast rice, alongside coenzyme Q10, grape seed, and olive leaf extracts. Over the treatment period, we found that both doses of monacolin K significantly reduced LDL cholesterol levels—26.46% with the higher dose and 16.77% with the lower dose.
While we saw some positive results relating to cholesterol reduction, the slight benefit attributed specifically to the coenzyme Q10 was not clearly defined, as it was part of a combination treatment. However, importantly, no severe adverse events were reported, suggesting that this supplement approach is safe for mild high cholesterol management. Overall, our findings suggest that lower-dose monacolin K combined with these natural extracts can be a helpful option for those looking to improve their cholesterol levels.
Read More
9
We delved into the effects of coenzyme Q10 (CoQ10) supplementation on cholesterol levels in adults to determine how it can influence lipid profiles. Through a thorough meta-analysis of fifty randomized controlled trials involving nearly 2800 participants, we explored its potential benefits for reducing cholesterol levels effectively.
Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.
Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.
Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.
Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.
Read More
9
We explored the effects of a combination of monacolin K, berberine, and coenzyme Q10 on cholesterol levels in individuals with moderate hypercholesterolemia and cardiovascular risk. This study involved patients divided into two groups: one received the nutraceutical preparation, while the other was given a placebo.
After three months, we observed a notable decrease in LDL cholesterol levels among those who took the nutraceutical, dropping by an impressive 26.1 mg/dL. In contrast, the placebo group showed a slight increase in LDL cholesterol. While non-HDL cholesterol and total cholesterol also decreased in the treatment group, measures like HDL cholesterol, triglycerides, and lipoprotein(a) remained unchanged in both groups.
Importantly, the combination demonstrated good tolerance and a safety profile throughout the study. Therefore, we conclude that coenzyme Q10, as part of this supplement, may be beneficial for lowering cholesterol levels alongside monacolin K and berberine in patients at risk for cardiovascular issues.
After three months, we observed a notable decrease in LDL cholesterol levels among those who took the nutraceutical, dropping by an impressive 26.1 mg/dL. In contrast, the placebo group showed a slight increase in LDL cholesterol. While non-HDL cholesterol and total cholesterol also decreased in the treatment group, measures like HDL cholesterol, triglycerides, and lipoprotein(a) remained unchanged in both groups.
Importantly, the combination demonstrated good tolerance and a safety profile throughout the study. Therefore, we conclude that coenzyme Q10, as part of this supplement, may be beneficial for lowering cholesterol levels alongside monacolin K and berberine in patients at risk for cardiovascular issues.
Read More
8
In this study, we explored how a dietary supplement, which includes coenzyme Q10 among other natural ingredients, affects high cholesterol levels in children and adolescents with moderate to severe hypercholesterolemia. The supplement, Armolipid, was given daily to 84 young participants, aiming to see if it could positively impact their cholesterol levels over time.
Our findings revealed that taking Armolipid led to significant decreases in total cholesterol and low-density lipoprotein cholesterol, which is often referred to as "bad" cholesterol. However, it's important to note that we didn't find any changes in high-density lipoprotein cholesterol, which is the "good" cholesterol, or in other lipid markers such as triglycerides.
Coenzyme Q10 was part of a combination treatment and its specific impact on cholesterol levels was challenging to isolate. While children who had previously used phytosterols saw additional improvements after starting Armolipid, the overall effects of coenzyme Q10 alone remain unclear.
Moving forward, more research involving larger groups of children is necessary to better understand the potential benefits of nutraceuticals like Armolipid in managing cholesterol levels in young people.
Our findings revealed that taking Armolipid led to significant decreases in total cholesterol and low-density lipoprotein cholesterol, which is often referred to as "bad" cholesterol. However, it's important to note that we didn't find any changes in high-density lipoprotein cholesterol, which is the "good" cholesterol, or in other lipid markers such as triglycerides.
Coenzyme Q10 was part of a combination treatment and its specific impact on cholesterol levels was challenging to isolate. While children who had previously used phytosterols saw additional improvements after starting Armolipid, the overall effects of coenzyme Q10 alone remain unclear.
Moving forward, more research involving larger groups of children is necessary to better understand the potential benefits of nutraceuticals like Armolipid in managing cholesterol levels in young people.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Youthful appearance
2 people found this helpful
This is my favourite product that I have used for years. It's helpful for blood pressure and cholesterol. I take one pill twice daily, and people often comment that I look younger than my age, thanks to this supplement. I’m delighted to have found it on iHerb due to their fast shipping and excellent prices!
Read More
9
Normalised heartbeat
1 people found this helpful
My husband has had a consistently high heartbeat. After starting this supplement once daily, his heartbeat is back to normal. It also provides a boost of energy and concentration. I’m thrilled that iHerb stocks the Qunol brand.
Read More
9
Eliminated aches
1 people found this helpful
My cholesterol medication caused muscle aches, but after adding CoQ10 to my regimen, my achy arms no longer hurt by week two. It works effectively!
Read More
9
Increased energy
1 people found this helpful
Coenzyme Q10 is my top supplement. It noticeably benefits my cardiovascular system, providing strength and energy. It’s been part of my family’s health routine for years, especially after my grandfather's heart attack. After suffering from coronavirus, I noticed improved energy and performance in the gym. This remains my favourite coenzyme.
Read More
9
Effective for cholesterol
1 people found this helpful
After just two months, my cholesterol decreased by 20 points. I suffered from debilitating muscle cramps due to bipolar medication, but this brand of CoQ10 has completely eliminated them.
Read More
Frequently Asked Questions
9
Effective for cholesterol
1 people found this helpful
After just two months, my cholesterol decreased by 20 points. I suffered from debilitating muscle cramps due to bipolar medication, but this brand of CoQ10 has completely eliminated them.
9
Reduced cholesterol significantly
1 people found this helpful
I took this product for just two months and it lowered my high cholesterol by 20 points. I also experienced severe muscle cramps due to bipolar medication, but those cramps have disappeared completely. From discussions with others on statins, I've learned they often suffer muscle issues, yet this version of CoQ10 has nearly eliminated them for me.
7.5
Cholesterol reduced
1 people found this helpful
It’s excellent for cardiovascular health. After six months of taking it without exercise, my health checks showed a reduction in triglycerides and cholesterol levels, now consistently within the standard range. I’ve purchased it repeatedly!
9
Increased energy
1 people found this helpful
Coenzyme Q10 is my top supplement. It noticeably benefits my cardiovascular system, providing strength and energy. It’s been part of my family’s health routine for years, especially after my grandfather's heart attack. After suffering from coronavirus, I noticed improved energy and performance in the gym. This remains my favourite coenzyme.
9
Eliminated aches
1 people found this helpful
My cholesterol medication caused muscle aches, but after adding CoQ10 to my regimen, my achy arms no longer hurt by week two. It works effectively!
7.5
Lowered blood pressure
1 people found this helpful
I hope this product stays available. With high blood pressure, taking it daily has significantly lowered my readings and made me feel healthy again. I appreciate the quality of this supplement.
9
Coenzyme Q10 aids cholesterol management
We explored the impact of coenzyme Q10 on high cholesterol in patients with polycystic ovary syndrome (PCOS) as part of a broader analysis of various nutritional supplements. The study involved a systematic review and network meta-analysis of forty-one randomized controlled trials, including 2,362 patients in total.
Our findings indicated that coenzyme Q10 was notably effective in improving lipid levels, particularly in reducing triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). It outperformed other supplements in these areas, suggesting that it may play a crucial role in managing cholesterol levels for individuals with PCOS.
However, it's important to note that while coenzyme Q10 demonstrated efficacy in lipid metabolism, the study did not show significant benefits for other health markers, like high-density lipoprotein cholesterol (HDL-C) or testosterone levels. This points to a need for more in-depth research to fully understand its potential and effectiveness in relation to individual health outcomes within this patient group.
Overall, our analysis suggests coenzyme Q10 could be a viable option for helping to manage high cholesterol in PCOS patients, although further high-quality studies are essential for confirming these results and understanding the broader implications.
Our findings indicated that coenzyme Q10 was notably effective in improving lipid levels, particularly in reducing triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). It outperformed other supplements in these areas, suggesting that it may play a crucial role in managing cholesterol levels for individuals with PCOS.
However, it's important to note that while coenzyme Q10 demonstrated efficacy in lipid metabolism, the study did not show significant benefits for other health markers, like high-density lipoprotein cholesterol (HDL-C) or testosterone levels. This points to a need for more in-depth research to fully understand its potential and effectiveness in relation to individual health outcomes within this patient group.
Overall, our analysis suggests coenzyme Q10 could be a viable option for helping to manage high cholesterol in PCOS patients, although further high-quality studies are essential for confirming these results and understanding the broader implications.
7
We aimed to understand how coenzyme Q10 (CoQ10), a nutrient found in various foods, influences cholesterol levels in adults. Through a national cross-sectional study of 7,938 participants from the China Health and Nutrition Survey, we assessed their dietary intake of CoQ10 over three days combined with an analysis of their lipid profiles.
Our findings revealed that the average intake of dietary CoQ10 was about 5.4 mg per day. Individuals who consumed higher amounts of CoQ10 (more than 6.96 mg per day) showed some interesting associations with their cholesterol levels. Specifically, we noted that this higher intake correlated with lower levels of total cholesterol, low-density lipoprotein (LDL-C), and non-high-density lipoprotein cholesterol (non-HDL-C).
On the flip side, those in the top quartile also had increased levels of apolipoprotein A-1 and triglycerides. While the observations pointed out some benefits regarding lipid profiles, it is essential to mention that using dietary CoQ10 may not be sufficient for individuals specifically seeking to manage high cholesterol through supplementation.
Overall, while our connections between dietary CoQ10 and certain cholesterol metrics are noteworthy, they suggest a more complex relationship where some individuals might still need direct supplementation for better results.
Our findings revealed that the average intake of dietary CoQ10 was about 5.4 mg per day. Individuals who consumed higher amounts of CoQ10 (more than 6.96 mg per day) showed some interesting associations with their cholesterol levels. Specifically, we noted that this higher intake correlated with lower levels of total cholesterol, low-density lipoprotein (LDL-C), and non-high-density lipoprotein cholesterol (non-HDL-C).
On the flip side, those in the top quartile also had increased levels of apolipoprotein A-1 and triglycerides. While the observations pointed out some benefits regarding lipid profiles, it is essential to mention that using dietary CoQ10 may not be sufficient for individuals specifically seeking to manage high cholesterol through supplementation.
Overall, while our connections between dietary CoQ10 and certain cholesterol metrics are noteworthy, they suggest a more complex relationship where some individuals might still need direct supplementation for better results.
8
In this study, we explored how a dietary supplement, which includes coenzyme Q10 among other natural ingredients, affects high cholesterol levels in children and adolescents with moderate to severe hypercholesterolemia. The supplement, Armolipid, was given daily to 84 young participants, aiming to see if it could positively impact their cholesterol levels over time.
Our findings revealed that taking Armolipid led to significant decreases in total cholesterol and low-density lipoprotein cholesterol, which is often referred to as "bad" cholesterol. However, it's important to note that we didn't find any changes in high-density lipoprotein cholesterol, which is the "good" cholesterol, or in other lipid markers such as triglycerides.
Coenzyme Q10 was part of a combination treatment and its specific impact on cholesterol levels was challenging to isolate. While children who had previously used phytosterols saw additional improvements after starting Armolipid, the overall effects of coenzyme Q10 alone remain unclear.
Moving forward, more research involving larger groups of children is necessary to better understand the potential benefits of nutraceuticals like Armolipid in managing cholesterol levels in young people.
Our findings revealed that taking Armolipid led to significant decreases in total cholesterol and low-density lipoprotein cholesterol, which is often referred to as "bad" cholesterol. However, it's important to note that we didn't find any changes in high-density lipoprotein cholesterol, which is the "good" cholesterol, or in other lipid markers such as triglycerides.
Coenzyme Q10 was part of a combination treatment and its specific impact on cholesterol levels was challenging to isolate. While children who had previously used phytosterols saw additional improvements after starting Armolipid, the overall effects of coenzyme Q10 alone remain unclear.
Moving forward, more research involving larger groups of children is necessary to better understand the potential benefits of nutraceuticals like Armolipid in managing cholesterol levels in young people.
7
We gathered insights from a comprehensive review that examined how coenzyme Q10 supplementation affects cholesterol levels in people with diabetic nephropathy. The review analyzed findings from multiple randomized controlled trials to assess the effectiveness of this treatment.
The results suggested that coenzyme Q10 supplementation may lead to improvements in several cholesterol markers. Specifically, we observed that there was moderate-quality evidence indicating significant reductions in total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels among patients receiving coenzyme Q10.
However, it's important to note that the evidence was rated as low quality regarding other cholesterol measures like high-density lipoprotein cholesterol (HDL-C), suggesting we should interpret these findings cautiously. Overall, while coenzyme Q10 shows potential benefits for high cholesterol, further research with larger sample sizes may be necessary for confirming these effects with greater certainty.
The results suggested that coenzyme Q10 supplementation may lead to improvements in several cholesterol markers. Specifically, we observed that there was moderate-quality evidence indicating significant reductions in total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels among patients receiving coenzyme Q10.
However, it's important to note that the evidence was rated as low quality regarding other cholesterol measures like high-density lipoprotein cholesterol (HDL-C), suggesting we should interpret these findings cautiously. Overall, while coenzyme Q10 shows potential benefits for high cholesterol, further research with larger sample sizes may be necessary for confirming these effects with greater certainty.
4
CoQ did not significantly lower cholesterol
We investigated how coenzyme Q10 (CoQ) impacts high cholesterol levels, especially in the context of a long-term study with zebrafish. Adult zebrafish were given high-cholesterol diets over 20 weeks, supplemented with either CoQ or beeswax alcohol (BWA) to compare their effects on dyslipidemia and organ health.
While CoQ was included in the study as a comparison, we found that its efficacy was overshadowed by BWA. Although we observed some positive effects on cholesterol levels from CoQ, BWA showed a more significant ability to reduce total cholesterol and triglycerides while boosting beneficial HDL cholesterol levels. The results suggested that BWA had a much better impact on preventing the health complications associated with high cholesterol diets than CoQ did.
Therefore, while CoQ was part of the research, particularly as a baseline to evaluate BWA, it ultimately did not demonstrate striking benefits in lowering high cholesterol or protecting against associated organ damage.
While CoQ was included in the study as a comparison, we found that its efficacy was overshadowed by BWA. Although we observed some positive effects on cholesterol levels from CoQ, BWA showed a more significant ability to reduce total cholesterol and triglycerides while boosting beneficial HDL cholesterol levels. The results suggested that BWA had a much better impact on preventing the health complications associated with high cholesterol diets than CoQ did.
Therefore, while CoQ was part of the research, particularly as a baseline to evaluate BWA, it ultimately did not demonstrate striking benefits in lowering high cholesterol or protecting against associated organ damage.
9
We delved into the effects of coenzyme Q10 (CoQ10) supplementation on cholesterol levels in adults to determine how it can influence lipid profiles. Through a thorough meta-analysis of fifty randomized controlled trials involving nearly 2800 participants, we explored its potential benefits for reducing cholesterol levels effectively.
Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.
Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.
Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.
Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.
8
CoQ10 improves cholesterol removal functions
We conducted a 24-week study to see how coenzyme Q10 (CoQ10) might help people with high cholesterol levels, specifically by examining its effects on high-density lipoprotein (HDL) function. A total of 101 participants with dyslipidemia were randomly assigned to either a CoQ10 group, which received 120 mg daily, or a placebo group.
We measured how well HDL could help remove cholesterol from the body, known as cholesterol efflux capacity (CEC), along with indicators of inflammation. Our results showed that those taking CoQ10 had a remarkable improvement in how effectively their HDL worked to remove cholesterol and also experienced a reduction in HDL inflammation after 24 weeks.
Interestingly, we noticed that the benefits of CoQ10 appeared to be even stronger in older adults, women, and non-obese individuals. However, CoQ10 didn’t make a significant difference in HDL oxidation levels. Overall, we found that adding CoQ10 to the diet could be a great way to enhance heart health for people struggling with high cholesterol.
We measured how well HDL could help remove cholesterol from the body, known as cholesterol efflux capacity (CEC), along with indicators of inflammation. Our results showed that those taking CoQ10 had a remarkable improvement in how effectively their HDL worked to remove cholesterol and also experienced a reduction in HDL inflammation after 24 weeks.
Interestingly, we noticed that the benefits of CoQ10 appeared to be even stronger in older adults, women, and non-obese individuals. However, CoQ10 didn’t make a significant difference in HDL oxidation levels. Overall, we found that adding CoQ10 to the diet could be a great way to enhance heart health for people struggling with high cholesterol.
References
- Garoufi A, Papadaki M, Kalogiannis M, Zerva U, Charakida M, et al. Beneficial Effects of a Nutraceutical Combination on Lipid Profiles in Children with Moderate and Severe Hypercholesterolemia. Biomolecules. 2024;14. doi:10.3390/biom14121608
- Cho KH, Lee Y, Bahuguna A, Lee SH, Yang CE, et al. The Consumption of Beeswax Alcohol (BWA, Raydel) Improved Zebrafish Motion and Swimming Endurance by Protecting the Brain and Liver from Oxidative Stress Induced by 24 Weeks of Supplementation with High-Cholesterol and D-Galactose Diets: A Comparative Analysis Between BWA and Coenzyme Q. Antioxidants (Basel). 2024;13. doi:10.3390/antiox13121488
- Zhao M, Tian Z, Zhao D, Kuang H, Liang Y, et al. Associations between dietary coenzyme Q10 intake and lipid profiles in adults: a national cross-sectional study. Front Nutr. 2024;11:1472002. doi:10.3389/fnut.2024.1472002
- Cho KH, Bahuguna A, Lee Y, Lee SH, Kim JE. Twenty-Week Dietary Supplementation with Beeswax Alcohol (BWA; Raydel) Ameliorates High-Cholesterol-Induced Long-Term Dyslipidemia and Organ Damage in Hyperlipidemic Zebrafish in a Dose-Dependent Manner: A Comparative Analysis Between BWA and Coenzyme Q. Pharmaceuticals (Basel). 2024;17. doi:10.3390/ph17111434
- Cai L, Huang Y, Li X, Cao D, Liu F. Effects of dietary intervention on diabetic nephropathy: an umbrella review of systematic reviews and meta-analyses of randomized controlled trials. Front Endocrinol (Lausanne). 2024;15:1385872. doi:10.3389/fendo.2024.1385872
- Hu X, Wang W, Su X, Peng H, Tan Z, et al. Comparison of nutritional supplements in improving glycolipid metabolism and endocrine function in polycystic ovary syndrome: a systematic review and network meta-analysis. PeerJ. 2023;11:e16410. doi:10.7717/peerj.16410
- Dahri M, Sarafan Sadeghi A, Pahlavani N, Nattagh-Eshtivani E, Hashemilar M, et al. The Effects of Coenzyme Q10 Supplementation on Oxidative Status and Lipid Profile in Migraine Patients: A Randomized Double-Blinded Controlled Clinical Trial. Clin Nutr Res. 2023;12:257. doi:10.7762/cnr.2023.12.4.257
- Angelopoulos N, Paparodis RD, Androulakis I, Boniakos A, Argyrakopoulou G, et al. Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipidemia: A Multicenter, Randomized Controlled Trial. Nutrients. 2023;15. doi:10.3390/nu15122682
- Liu Z, Tian Z, Zhao D, Liang Y, Dai S, et al. Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials. J Clin Endocrinol Metab. 2022;108:232. doi:10.1210/clinem/dgac585
- Fahmy MIM, Sayed RH, El-Yamany MF, El-Naggar R, A Eliwa H. Rosuvastatin and co-enzyme Q improve high-fat and high-fructose diet-induced metabolic syndrome in rats via ameliorating inflammatory and oxidative burden. Biomed Pharmacother. 2022;153:113526. doi:10.1016/j.biopha.2022.113526
- Zou J, Tian Z, Zhao Y, Qiu X, Mao Y, et al. Coenzyme Q10 supplementation improves cholesterol efflux capacity and antiinflammatory properties of high-density lipoprotein in Chinese adults with dyslipidemia. Nutrition. 2022;101:111703. doi:10.1016/j.nut.2022.111703
- Martinez-Martin F, Corbella E, Sarasa I, Trias F, Petitbò D, et al. Effects of treatment with monacolin K, berberine and coenzyme Q10 on lipid metabolism in patients with moderate cardiovascular risk. Semergen. 2022;48:403. doi:10.1016/j.semerg.2022.04.005
